BCPS 2013: Pediatric Seizures

wpid-Photo-Feb-3-2013-1021-PM.jpg

Pediatric Seizures

Partial - VPA, CBZ, PHT PB, gabapentin, lamotrigine, tiagabine, topiramate, oxcarbazepine, zonisamide, levetiracetam

Generalized:

Tonic-clonic - VPA, CBZ, PHT Lamotrigine, topiramate, zonisamide, levetiracetam

Myoclonic - VPA Topiramate, zonisamide, levetiracetam

Absence - Ethosuximide, VPA Lamotrigine, zonisamide, levetiracetam

Lennox-Gastaut - VPA, topiramate, lamotrigine Rufinamide, clobazam, felbamate, zonisamide

Infantile spasms - ACTH Vigabatrin, lamotrigine, tiagabine, topiramate, VPA, zonisamide

Know the adverse effects and pharmacokinetics interactions of the medications listed above. Think about a scenario. Teen girl has acne, overweight, and seizures. Phenytoin should immediately be crossed of the list because of its side effect profile. Which drugs affect birth control pills effectiveness?

What type of seizure does ACTH cover? What type of seizure does ethosuximide cover?

I will start adding my Flashcards to these topics this week.

BCPS 2013: Pediatrics Otitis Media

Such a fun topic!  Who loves it when the kid says his/her ear hurts?  I cringe just thinking about this one: Otitis Media:  The Bane of all Daycare and all School-aged Youngsters

Common Pathogens

  • Viral
  • S. pneumoniae
  • Nontypeable H. influenzae
  • Moraxella catarrhalis

Treatment

  • Watch and wait if > 2 yo and pain/fever less than 48-72 hours
  • Bulging tympanic membrane/perforation = antibiotics
  • Always antibiotics if < 6 months old 4. Middle ear fluid does not indicate repeated treatment unless persists > 3 months
  • Corticosteroids, antihistamines, and decongestants are not recommended

Antibiotic regimens a. Amoxicillin (high dose: 80–90 mg/kg/day): Recommended by AAP as the first-line therapy for acute otitis media b. Amoxicillin/clavulanate c. Cefuroxime d. Other antibiotic options (e.g., cefdinir, cefpodoxime) may be effective. e. Duration i. The most appropriate duration is unclear. ii. In general, 7–10 days, but a shorter course (5 days) has been used in children older than 2 years iii. For confirmed cases of acute otitis media not responding to the initial antimicrobial regimen within 48–72 hours, a change in antibiotic regimen is warranted. Failure of the the above warrants ceftriaxone IM for 3 days or tubes i. Intramuscular ceftriaxone may also be considered if adherence is a concern. ii. Tympanostomy with tube placement may be most beneficial for children with persistent otitis media with effusions and significant hearing loss (e.g., greater than 25-dB hearing loss in both ears for more than 12 weeks).

Prophylaxisotitis media 1. Reserved for patients with recurrent acute otitis media 2. Reduces occurrence by about one episode per year 3. The risk of promoting bacterial resistance may outweigh the slight benefit

BCPS 2013: Pediatrics

I feel I have a bit of insight into the test and can attest to what is needed to know in each section.  Keep in mind the guidelines could change between 2012 and 2013 along with the test questions, but for the most part I found the test to be incredibly fair though stressing areas more than others that I would have not expected. I want you to pass!  First attempt!

So what do you need to do to pass?  Start now.  I especially am talking to those with families and/or children and very little time to spare for sitting down and studying the traditional way.  Again, I did fail this past year, so I will disclose that immediately, but I do believe I have insight into the test and very much plan to pass it this fall.  It's a goal at this point for my own personal development.

So, ahead I will have some material presented that does come from the ACCP study material though reworded and simplified in more study form and perhaps some hints as to what was important on the test in each particular section.  I am hoping to not get in any sort of trouble by doing this as far as with the BPS, so if this is not appropriate, would someone from there contact me?  I do not plan on giving test questions per se' and I couldn't if I tried as there were far too many to memorize.

After two children I am convinced parts of my brain were delivered with the children as it is.

First up!  PEDIATRICS!BCPS pediatrics

This was always the topic that would terrify me prior to having children, but at this point besides missing one of the most common concepts of children and the very small amount of data on the test regarding pediatrics (at least in my opinion), pediatrics just doesn't seem so daunting.

Know the common pathogens of children in sepsis and meningitis.

0–1 month  

  • Group B streptococcus
  • Escherichia coli
  • Listeria monocytogenes
  • Viral (e.g., herpes simplex virus)
  • Coagulase-negative staphylococcus—nosocomial
  • Gram (−) bacteria (e.g., Pseudomonas spp., Enterobacter spp.)
  • nosocomial

1–3 months

  • Neonatal pathogens (see above)
  • Haemophilus influenzae type B
  • Neisseria meningitidis
  • Streptococcus pneumoniae

3 months–12 years

  • H. influenzae type Ba
  • N. meningitidis
  • S. pneumoniae

> 12 years

  • N. meningitidis
  • S. pneumonia

Not to hard to figure out correct?  Keep in mind that H. flu is less and less due to immunizations.  I suppose if you live in an area where vaccination is the devil, you may find more of this organism.

 

Potential Antibiotic Regimens

Age                                                                         Regimen

0–1 month                                                            Ampicillin + gentamicin OR ampicillin + cefotaxime

1–3 months                                                          Ampicillin + cefotaxime/ceftriaxone

3 months–12 years                                             Ceftriaxone ± vancomycina

> 12 years                                                             Ceftriaxone ± vancomycina

**Addition of vancomycin should be based on the regional incidence of resistant S. pneumoniae.

                               

Regimens for Chemoprophylaxis  (I will have to reformat this later)

Drug                      Neisseria meningitidis                                                                       Haemophilus influenzae

Rifampin            < 1 month old: 5 mg/kg/dose PO every 12 hours × 2 days                       20 mg/kg/dose (maximum 600 mg)

> 1 month old: 10 mg/kg/dose PO every 12 hours × 2 days                   daily x 4 days

Adults: 600 mg PO every 12 hours × 2 days

 

 

Ceftriaxone             < 15 years old: 125 mg IM × 1 dose                                                               Not indicated

> 15 years old: 250 mg IM × 1 dose

 

**Ciprofloxacin and azithromycin are possible alternatives although not routinely recommended.

 

RSV - Identify the drugs available for preventing and treating respiratory syncytial virus.

Prophylaxis

  1. Nonpharmacologic: Avoid crowds during RSV season and conscientiously use good hand-washing practice.
  2. RSV IVIG (RespiGam): No longer marketed in the United States (didn't see on the test ;))
  3. Palivizumab (Synagis)
  • a. Dosing: 15 mg/kg/dose intramuscularly; given monthly during RSV season
  • b. Effects on outcomes

i. A 55% reduction in hospitalizations for RSV

ii. Safe in patients with cyanotic congenital heart disease

iii. No reduction in overall mortality

iv. Does not interfere with the response to vaccines

v. Not recommended for the prevention of nosocomial transmission of RSV

Know this:  Supportive care.  Treatment is supportive care only.

 

American Academy of Pediatrics Palivizumab approval:  (you WILL see this)

 

i. Premature infants born before 32 weeks’ gestation (i.e., 31 weeks, 6 days or earlier) who are 6 months old or younger at the beginning of RSV season

(a) Infants born at less than 28 weeks’ gestation may benefit up to 12 months of age.

(b) Eligible for a maximum of five doses of palivizumab during RSV season

 

ii. Infants with chronic lung disease who are 2 years or younger and who required medical management of their chronic lung disease in the previous 6 months – Eligible for a maximum of five doses of palivizumab during RSV season

 

iii. 32 and 35 weeks’ gestation (i.e., 32 weeks, 0 days through 34 weeks, 6 days) who are 3 months or younger at the beginning of RSV season

(a) With at least one of the following risk factors may benefit: infant attends childcare or sibling younger than 5 yo in same household

(b) Eligible for a maximum of three doses of palivizumab during RSV season

 

iv. Infants 24 months and younger with hemodynamically significant congenital heart disease

(a) Eligible for a maximum of five doses of palivizumab during RSV season

(b) There is a 58% decrease in palivizumab serum concentration after cardiopulmonary bypass; therefore, a postoperative dose of palivizumab is recommended as soon as the patient is medically stable.

 

v. Infants 12 months and younger with congenital abnormalities of the airway or neuromuscular disease that compromises the handling of respiratory tract secretions – Eligible for a maximum of five doses of palivizumab during RSV

 

Tomorrow will continue with otitis media...